Photodynamic Therapy-Lots of Questions But Presently Few Answers

Photodynamic therapy--lots of questions but presently few answers.

The elimination of malignancy is the ultimate oncologic goal. Many tumors can be killed by large amounts of chemotherapy or ionizing radiation. Unfortunately, host tolerance to treatment frequently limits the extent to which these modalities can be used. Therefore, skilled use of effective but nonselective modalities is the present basis of oncology. The recent clinical interest in the use of p...

Use of biomarkers in sepsis: many questions, few answers

Why do we use biomarkers in sepsis? There are several answers to this question. Some researchers argue that biomarkers are used to assess the prognosis of septic patients, (1) but why should we use a biomarker merely to determine whether a patient has a higher risk of death when currently available interventions are not able to modify the prognosis? (2) As we all know, dozens of randomized cont...

Compatible solute influence on nucleic acids: Many questions but few answers

Compatible solutes are small organic osmolytes including but not limited to sugars, polyols, amino acids, and their derivatives. They are compatible with cell metabolism even at molar concentrations. A variety of organisms synthesize or take up compatible solutes for adaptation to extreme environments. In addition to their protective action on whole cells, compatible solutes display significant...

Language and hybrids: too many answers for too few questions.

Osteopathic manipulative treatment for pandemic influenza: many questions, few answers

In this volume, an article by Hruby and Hoffman titled "Avian influenza: an osteopathic component to treatment" proposes the use of osteopathic manipulative treatment (OMT) as an adjunct to other forms of therapy in the management of a potential pandemic of avian influenza or "bird flu" [1]. This article is certainly timely and presents a much-needed reminder of the potential use of OMT in the ...